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What is ketamine infusion therapy​?

What is Ketamine Infusion Therapy?

Ketamine infusion therapy is a precision medical treatment where low, sub-anesthetic doses of ketamine are delivered directly into the bloodstream through an IV (intravenous infusion).

It is important to understand that this clinical protocol is vastly different from the high doses used in traditional surgery or the misuse of the substance in recreational settings. At the Ketamine Center of Connecticut, every infusion session is carefully monitored and tailored to the individual, ensuring a safe, controlled, and therapeutic experience designed specifically for mental health recovery.

This naturally raises important questions:

what is ketamine infusion therapy

How does ketamine infusion therapy work for depression and anxiety?

Ketamine infusion therapy works differently from standard antidepressants. Instead of acting on serotonin or dopamine, it targets glutamate pathways in the brain. This precision approach quickly improves communication between neurons and promotes the regrowth of synapses the vital connections in the brain’s circuitry.

Researchers believe this surge in neuroplasticity the brain’s ability to form and strengthen new connections creates a “critical window” of opportunity. During this time, patients are often more open to new ways of thinking and responding. This is why ketamine infusions are often combined with psychotherapy, such as CBT, to help patients solidify lasting changes.

This treatment is typically considered for individuals struggling with treatment-resistant depression or anxiety who haven’t seen improvement after trying at least two standard antidepressant medications.

Deep Dive: We have published several in-depth clinical reviews and patient guides that explore the science behind these breakthroughs. You can explore these resources in our
Comprehensive Ketamine Research Blog.

What are the risks and side effects of ketamine infusion therapy?

Research over the last 5-10 years has shown that intravenous administration of ketamine in sub-anesthetic doses remarkably benefits 70% of people suffering from severe depression.

Clinical Evidence: This high response rate for treatment-resistant cases is documented in research archived by the National Institutes of Health (PMC).

While the benefits can truly be remarkable, they often occur in ways that differ from some patients’ expectations. The changes produced by ketamine can be subtle; while they occur quickly, they do not always manifest themselves immediately.

Safety and Specialist Oversight

Ketamine has been used as an anesthetic and pain relief medication in operating rooms for decades. It is an exceptionally safe medication for depression when managed by properly trained healthcare professionals. Anesthesiologists like Dr. Gino are the most highly trained physicians in the safe and precise use of ketamine.

Its use for treatment-resistant depression and other mental health conditions is conducted at sub-anesthetic doses—levels well below those necessary to induce general anesthesia. Ketamine is also frequently utilized to treat patients experiencing chronic pain conditions.

Managing the Infusion Experience

During an infusion session, most patients experience a mild dissociation or an inner reflective experience that is generally well-tolerated.

  • Real-Time Care: If you experience nausea, mild anxiety, or any unpleasant sensations, our medical team will be there to treat you and ensure your comfort immediately.

  • Rapid Recovery: Within 15 minutes of ending the infusion, your thinking will be clear.

  • Post-Treatment Safety: Because your safety is our priority, you will need a designated driver to take you home from our Milford or Westport clinics following the appointment.

What are the risks and side effects of ketamine infusion therapy?

Ketamine treatment is not recommended for individuals who are pregnant or breastfeeding, as the potential risks to the fetus or infant have not been fully established.

Additionally, safety is our primary concern at the Ketamine Center of Connecticut. Certain medical conditions are considered contraindications because they may interfere with the safe administration of the medication:

  • Uncontrolled Cardiovascular Issues: Ketamine is contraindicated in patients with uncontrolled or untreated high blood pressure, since ketamine infusions may elevate blood pressure and increase cardiovascular risk.

  • Thyroid Disorders: Those with untreated hyperthyroidism should avoid ketamine therapy, as the condition may amplify cardiovascular effects and lead to complications.

  • Active Substance Use: Certain active substance use disorders may also preclude treatment to ensure the ketamine infusion remains therapeutic and safe.

Before beginning care, Dr. Gino conducts a comprehensive medical screening at our Milford or Westport clinics to ensure that ketamine infusion therapy is a safe and appropriate option for your health profile.

Does ketamine treatment work better than talk therapy or daily medication?

The answer is both yes and no. Ketamine infusion therapy has shown significant results compared to traditional talk therapy or daily medications, often providing faster relief for those with treatment-resistant depression.

However, for long-term effectiveness, we recommend a “whole-patient” approach. Combining ketamine infusions with professional counseling and prescribed medication often yields the best results. While ketamine may provide rapid biological improvement, those effects are most sustainable when supported by continued therapeutic care.

At the Ketamine Center of CT, your health is our top priority. Our goal is to help ease lifelong pain, support your mental wellness, and provide the clinical foundation you need to endure and thrive

Frequently Asked Question

No solid food for 4 hours before a ketamine infusion. Clear liquids only 2 hours before the infusion. 

No solid food for 4 hours before a ketamine infusion. Clear liquids only 2 hours before the infusion. 

 

We specialize in IV Ketamine infusions because they offer 100% bioavailability. Unlike nasal sprays, which can be affected by congestion or individual anatomy, IV delivery ensures the exact dose reaches your bloodstream instantly, allowing for precise medical control.

 

 While the FDA approved Ketamine as an anesthetic, its use for mental health is considered “off-label.” This is a common and legal medical practice where a safe, approved medication is used for a new purpose based on strong clinical evidence.

Conclusion

Ketamine infusion therapy is a safe, evidence-based medical treatment that is increasingly used to provide rapid relief, particularly for patients struggling with severe depression or suicidal thoughts.

While traditional counseling and daily medications are effective for many, they often take weeks or months to show results. Ketamine infusions can help bridge that gap by offering faster biological relief. However, this treatment works best as part of a comprehensive plan. When combined with ongoing psychotherapy and prescribed medications, it provides the strongest foundation for long-term recovery and mental wellness.

At the Ketamine Center of Connecticut, led by Dr. Gino Ang, we are dedicated to helping you find the breakthrough you’ve been searching for.

References

https://www.yalemedicine.org/news/ketamine-for-depression 

“Ketamine For Depression: What You Need To Know” — Mayo Clinic’s MCPress page citing a “response rates as high as 70%” in clinical trials. Mayo Clinic News Network

“Intravenous Ketamine for Treatment-Resistant Depression (G2K)” — Mayo Clinic’s clinical trials page. mayo.edu

Conclusion

KetamineCenterOffice

Ketamine treatment is available at our two Connecticut locations:

232 Boston Post Rd Suite 13, Milford, CT 06460
 1720 Post Rd E Suite 222, Westport, CT 06880

Treatments are strictly supervised by a board-certified physician, Dr. Gino Ang. Ketamine is prescribed only for adults with major depressive disorder who have not responded adequately to at least two different antidepressants. All treatment sessions are conducted in a controlled clinical environment, and Ketamine is administered under the physician’s direct supervision.

Patients must follow strict protocols:

  • Ketamine is prescribed and monitored only by a qualified physician.
  • Treatment is delivered in-office with continuous medical oversight.
  • Use of ketamine outside this controlled setting is unsafe and not permitted.

If you are experiencing symptoms of depression and want to explore ketamine treatment, please contact us to schedule a consultation at our Milford or Westport clinic. All care is personalized to ensure safety, efficacy, and adherence to clinical guidelines.

Doctor-Ang

Dr. Gino Ang MD 

Board-Certified Anesthesiologist 

Medical Review & Disclaimer

This content was reviewed for medical accuracy by Dr. Gino of the Ketamine Center of CT. This information is for educational purposes and is not a substitute for professional medical advice, diagnosis, or treatment. Use of this site does not establish a doctor-patient relationship.

Take the Next Step Toward Relief

If you’ve been searching for a treatment that offers real, rapid, and lasting improvement even when other options haven’t helped ketamine therapy may be the answer. Our team is here to guide you with compassion, expertise, and personalized care every step of the way.
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