What is ketamine infusion therapy
Ketamine infusion therapy
is a medical treatment where low doses of ketamine are delivered directly into the bloodstream through an IV (intravenous infusion). It’s not the same as the higher doses once known for anesthesia or recreational use this is carefully .
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How does ketamine infusion therapy work for depression and anxiety?
Ketamine infusion therapy works differently from standard antidepressants. Instead of acting on serotonin or dopamine, it targets glutamate pathways in the brain. This can quickly improve communication between neurons and promote regrowth of synapses (connections in the brain’s circuitry).
Researchers believe this surge in neuroplasticity, the brain’s ability to form new connections, creates a “critical window” where patients are more open to new ways of thinking and responding. That’s why ketamine is often combined with psychotherapy, like CBT, to help patients make lasting changes.
It’s typically considered for people with depression or anxiety who haven’t improved after trying at least two standard antidepressant medications.
What are the risks and side effects of ketamine infusion therapy?
Also, research over the last 5-10 years has shown that intravenous administration of ketamine in sub-anesthetic doses remarkably benefits 70% of people suffering from severe depression.While the benefits can truly be remarkable, they often occur in ways that differ from some patients’ expectations. That is, the changes produced by ketamine can be subtle, and while they occur quickly, they do not always manifest themselves immediately.
Ketamine has been used as an anesthetic and pain relief medication in operating rooms for decades. It is a very safe depression medication in the hands of properly trained healthcare professionals. Anesthesiologists are the most highly trained physicians when it comes to the safe use of ketamine.Its use as a treatment for depression, including treatment resistant depression, and other mental health conditions is at sub-anesthetic doses, below those necessary to induce general anesthesia. Ketamine is also frequently used to treat patients experiencing chronic pain conditions.
Most patients experience a mild dissociation or inner reflective experience that is generally well tolerated. If you experience nausea, mild anxiety or any unpleasant sensations we will be there to treat you and take care of you. Within 15 minutes of ending the infusion, your thinking will be clear.
Are there any medical conditions that would preclude ketamine infusion therapy?
Ketamine treatment is not recommended for individuals who are pregnant or breastfeeding, as the potential risks to the fetus or infant have not been fully established. It is also contraindicated in patients with uncontrolled or untreated high blood pressure, since ketamine may elevate blood pressure and increase cardiovascular risk. Similarly, those with untreated hyperthyroidism should avoid ketamine therapy, as the condition may amplify the cardiovascular effects and lead to complications.
Does ketamine treatment work better than talk therapy or daily medication?
Conclussion
Ketamine infusion therapy is considered safe and is increasingly used in medical settings to provide rapid relief, particularly for patients struggling with severe depression or suicidal thoughts. While counseling and daily medications are effective, they often take weeks or months to show results. Ketamine infusion therapy can help bridge that gap by offering faster relief, but it works best when combined with ongoing treatments such as therapy and prescribed medications for long-term recovery.
References
https://www.yalemedicine.org/news/ketamine-for-depression
“Ketamine For Depression: What You Need To Know” — Mayo Clinic’s MCPress page citing a “response rates as high as 70%” in clinical trials. Mayo Clinic News Network
“Intravenous Ketamine for Treatment-Resistant Depression (G2K)” — Mayo Clinic’s clinical trials page. mayo.edu